منابع مشابه
Long QT syndrome: A therapeutic challenge
Congenital long QT syndrome (LQTS) is one of the most common cardiac channelopathies and is characterized by prolonged ventricular repolarization and life-threatening arrhythmias. The mortality is high among untreated patients. The identification of several LQTS genes has had a major impact on the management strategy for both patients and family members. An impressive genotype-phenotype correla...
متن کاملThe long QT syndrome: therapeutic implications of a genetic diagnosis.
The congenital long QT syndrome (LQTS) is a hereditary disorder characterized by a prolonged QT interval and a polymorphic ventricular tachycardia, known as torsade de pointes (TdP), leading to severe cardiac events such as syncope and/or sudden cardiac death. Molecular genetic studies have revealed a total of eight forms of congenital LQTS caused by mutations in genes of the potassium, sodium ...
متن کاملLong QT Syndrome
Background. Erythromycin is known to prolong ventricular repolarization and has been associated with the occurrence of torsades de pointes. In this study, we have investigated potential mechanisms in vivo and in vitro for induction of an acquired long QT syndrome by erythromycin. Methods and Results. Ventricular electrograms and endocardial monophasic action potentials were recorded in anesthet...
متن کاملThe Long QT Syndrome
Introduction The Long QT syndrome (LQTS) can be inherited or acquired and is of particular interest and concern at present. Patients with LQTS are predisposed to the ventricular tachyarrhythmia torsade de pointes (TdP) which causes syncope and sudden death. Inherited LQTS is the prototype of the "primary cardiac arrhythmias" or "cardiac ion channelopathies". The study of inherited LQTS has prov...
متن کاملLong Qt Syndrome
Department of Biology, National Taiwan Normal University, Taipei; Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University, Taipei; Department of Internal Medicine, Wei Gong Memorial Hospital, Tou Fen, Miaoli; Division of Cardiology, Department of Medicine, Veterans General Hospital-Taipei; and Department of Medical Research and Education, Veterans General Hospita...
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ژورنال
عنوان ژورنال: Annals of Pediatric Cardiology
سال: 2008
ISSN: 0974-2069
DOI: 10.4103/0974-2069.41051